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While researchers catalogued the mitochondrial genome's thirteen protein-coding genes, they overlooked the possibility that its short open reading frames, sequences long dismissed as genomic noise, might encode biologically active peptides

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A 2025 correction and re-analysis of cell-line data (PMID 41240216) reported dose-dependent telomere length extension in normal breast epithelial and fibroblast cell lines following Epitalon treatment, attributed to upregulation of hTERT mRNA expression and telomerase enzyme activity

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